Salman N Adil, Adnan Qureshi.
Von Willebrand disease - an under diagnosed entity.
J Pak Med Assoc Jan ;58(4):157-8.

von Willebrand factor (VWF) is a central component of haemostasis serving both as a carrier of factor VIII and as an adhesive link between platelets and the injured blood vessel wall.1 Defects in VWF, therefore, may cause bleeding by impairing both platelets adhesion and blood clotting. Von Willebrand disease (VWD) has been defined as an inherited bleeding disorder caused by a quantitative or qualitative defect of VWF secondary to a mutation in VWF gene located on chromosome 12.2 VWD has been classified into three different types: type 1 and 3 refers to a partial and complete deficiency of VWF respectively, while type 2 includes the qualitative abnormalities of VWF structure and / or function. Type 2 VWD is further subdivided into subtype A, B, M and N. This is an Editorial.

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