Abolfazl Bohlouli, Mohammad Ebrahim Ebrahimzadeh, Hossein Samadi Kafil, Mohammad Asgharzadeh.
Evaluation Mannose - binding lectin gene and promoter polymorphism in renal transplant recipients.
J Pak Med Assoc Jan ;58(6):294-8.

Objective: The aim of present study was to determine the distribution of the alleles of mannose-binding lectin gene and promoter variants in renal transplant recipients and seek correlation between these variants and diseases that cause renal dysfunctions. Methods: One hundred and thirteen renal recipients` samples were compared with 120 normal controls from Azarbaijan population of Iran. Blood samples were obtained from renal transplant recipients who received a kidney between March 2004 and July 2005. Mannose-binding lectin genotypes were investigated by polymerase chain reaction and restriction fragment length polymorphism. Results: Allelic and genotypic frequency of the polymorphism at position- 550, -221, +4 and at codon 52, 54 and 57 did not show statistical differences between recipients and controls (P>0.05) but significant frequency of allele B (codon 54) (P=0.02) and Lx haplotype (P=0.002) of promoter was observed in patients with Lupus Erythematosus and infection source of renal dysfunctions. Conclusion: Our findings provide evidence that presence of different alleles and haplotypes that cause low concentration of mannose-binding lectin in serum is a risk factor for severity of systemic Lupus Erythematosus and susceptibility to renal infections that cause renal dysfunction (JPMA 58:294;2008).

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