Wan Omar A, Ngah Z U, Zaridah M Z, Noor Rain A.
In vitro and in vivo antiplasmodial properties of some Malaysian plants used in traditional medicine.
Infect Dis J Jan ;16(4):97-101.

Ten Malaysian medicinal plants were screened for their antiplasmodial activities. These plants were selected based on their traditional claims for treatment of ailments or to relieve fever. For their in vitro antiplasmodial activities, the FCR-3 strain of Plasmodium falciparum was used as target while the cytotoxic activities were carried out against Madin- Darby bovine kidney (MDBK) cells using Mtt assay. The 7-day suppressive test was employed to determine the parasitemia suppression of the plant extracts against P. berghei. Four of these plants produced considerable antimalarial effects. Their percentage inhibition was more than 50% inhibition to parasite growth at the 0.03 ug/ml extract concentrations. Tinospora crispa showed the maximum at 90 % inhibition, followed by Andrographis paniculata at 80 % and Jasminium sambac and Xylocarpus granatum both at 70 %. After 7 days of treatment with the methanol extract, mean parasitemia suppression in the P. berghei-infected mice ranged from 1.14+0.22 at day 1 to 50.73+1.32 at day 6. Mice that survived until the sixth day were those treated with T. crispa (n=3) and J. sambac (n=2). All these plants have traditional claims for relief of fever and this study provides a preliminary scientific evidence for the claims.

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