Javed lqbal Farooqi, Rukhsana Javed Farooqi.
Role of Octreotide in Chemo and Radiotherapy induced Diarrhea.
J Coll Physicians Surg Pak Jan ;10(3):93-4.

An interventional, quasi-experimental, clinical trial of `before-and-after type was conducted to find out the role of octreotide in chemo and radiotherapy-induced diarrhea on thirty patients. Among these 19 patients had advanced cancer and 11 with acute leukemia. All patients were given IV fluids and Loperamide for 5 days. The patients who did not respond during this period were administered with octreotide subcutaneously for another 5 days and response against diarrhea was noted. We found that only 10% patients responded to loperamide therapy whereas in the remainIng 90% patients an excellent response was noted as 96.29% of these patients responded to octreotide therapy which stopped their diarrhea (P< 0.005) leading us to the conclusion that, octreotide is a safe and effective drug in the management of chemo and radiotherapy-induced diarrhea.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com