Mohammad Haroon Yousuf, Hafiz Abdul Rauf, Mirza llyas Baig, Muhammad Akram, Zahid Rizwan.
Initial Management of Acute Variceal Haemorrhage Comparison of Octreotide and Sclerotherapy.
J Coll Physicians Surg Pak Jan ;10(3):95-7.
A randomised-controlled trial was conducted to compare the efficacy of subcutaneous injection of Octreotide (Sandostatin) and Sclerotherapy in 96 cirrhotic patients with endoscopically proven bleeding oesophageal varices. Fortyeight patients received subcutaneous injection of octreotide in a dose of 50 micrograms six hourly and another 48 patients received sclerotherapy. Complete control of bleeding was achieved in 82%a patients of octreotide group and 90% patients of sclerotherapy group after 72 hours. Mortality related to bleeding oesophageal varices was different in the two groups. This study reports that octreotide is as effective as sclerotherapy in the initial controlling of acute oesophageal variceal bleeding until an elective endoscopic sclerotherapy could be performed.
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