Fazila Hashmi, Faisal G Siddiqui, Akmal Jamal.
Role of topical glyceryl trinitrate as an adjunct following Milligan-Morgan`s Hemorrhoidectomy.
J Surg Pak Jan ;13(3):108-11.

Objectives: To assess the efficacy of topical glyceryl trinitrate (GTN) when used in post-operative period after haemorrhoidectomy in terms of rapid wound healing in a shorter period along with pain reduction. Study design: Comparative trial Place and duration of study: Department of surgery, Liaquat University Hospital Jamshoro, from February 2007 to August 2007. Patients and Methods: A randomized, single blinded trial was carried out over a period of six months. Patients were randomized to receive either GTN or Polymyxin ointment. Patients with comorbids that contraindicate the use of GTN were excluded from the study. Inferential and descriptive statistics were calculated using SPSS version 10.0. Results: Sixty patients were recruited. There were no statistically significant differences noted in gender, age and degree of haemorrhoids. Pain perception was also statistically insignificant in both the groups, however, a significant number of patients (20 out of 30) showed complete wound healing at 4th week of surgery. This was a statistically significant finding (p=0.004). None of the patients in polymyxin group experienced headaches but this was observed in three patients who received GTN. Conclusions: Topical GTN is an effective agent in hastening wound healing after Milligans-Morgan haemorrhoidectomy. Its role in better management of pain was, however not observed.

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