Asif Irfan, Mohammad Farooq.
Therapeutic options in nonulcer dyspepsia.
Pak J Med Res Jan ;47(1):14-7.

Backround: The exact cause of non ulcer dyspepsia is not known. Therefore the treatment of non ulcer dyspepsia is largely empirical.1 We need to find out the most effective therapy for this disease. Purpose of study: Evidence for the effectiveness of antacids, histamine-2 receptor antagonists, bismuth salts, sucralfate and prokinetic therapy in non-ulcer dyspepsia is conflicting. Antisecretory and prokinetics drugs are used in the treatment of non-ulcer dyspepsia (NUD). We conducted a randomized trial for evaluating these therapies in non-ulcer dyspepsia. Patients and methods: Two hundred and fifty patients of dyspepsia were studied. Gastroscopy and ultrasound of the gall bladder was done. Ninety six patients turned out to be suffering from nonulcer dyspepsia. They were randomly given antisecretory and prokinetics medication one after the other for a period of two weeks each. Symptom scoring was done on a four-point scale. Results: Out of 96 patients of NUD 53(55.20%) reported improvement with antisecretory drugs, 27(28.12%) found relief with Prokinetic drugs but 16(16.66%) did not get relief from any drug. Statistical analysis revealed that antisecretory medication is more effective in the treatment of non-ulcer dyspepsia compared to the prokinetics drugs. A subgroup analysis of ulcer type NUD and dysmotility type NUD also showed the same results. Conclusions: Antisecretory drugs are more effective than prokinetics drugs in the treatment of non-ulcer dyspepsia. They are effective in the ulcer type and dysmotility type of NUD.

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