Rabia Rathore, Nasir Farooq Butt, Sarah Shoaib, Adil Iqbal, Zafarullah Khan.
Diabetes Mellitus in patients with decompensated liver disease due to Hepatitis C.
Esculapio J Services Inst Med Sci Jan ;3(4):6-9.

Background: Chronic liver disease is very common in Pakistan and so are its complications. It carries a high mortality and morbidity. Diabetes mellitus is a syndrome with disordered metabolism either due to insulin deficiency or insulin resistance. The major mechanism for diabetes to occur in cirrhotics appears to be insulin resistance which is related to fibrosis score. Liver inflammation or damage of liver may affect the metabolism of insulin. Objective: The objective of this study was to find out the percentage of people who develop diabetes mellitus after developing chronic liver disease due to hepatitis C. Method: 100 patients presenting to medical wards of Mayo hospital, Lahore were studied. Patients of chronic liver disease and diabetes mellitus were selected on the basis of history, examination and laboratory investigations which included liver function tests, anti HCV, serum albumin, prothrombin time, abdominal ultrasound, gastroscopy, fasting and random blood sugar levels. Results: It was found that out of 100 selected patients 32 (32%) had diabetes mellitus; 24 were males while 8 were females. All of these patients developed diabetes mellitus after developing cirrhosis due to hepatitis C infection. Conclusion: The principle conclusion of the study was that patients with decompensated cirrhosis due to hepatitis C had significantly higher proportion of diabetes mellitus than general population.

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