Mona Soliman, Abdul Majid Al Drees.
Myocardial protection by Ethyl-Isopropyl amiloride, a specific Na+-H+ exchange inhibitor, following Hemorrhagic Shock.
Pak J Med Sci Jan ;25(2):289-92.

Background: Hemorrhagic shock and resuscitation is well known to result in myocardial dysfunction and injury. Stimulation of the Na+-H+ exchanger plays an important role in the pathway of myocardial injury. The purpose of the present study was to examine the protective effects of blocking the cardiac Na+-H+ exchange, using 100mM ethyl-isopropyl amiloride (EIPA), a specific Na+-H+ exchanger blocker, on myocardial contractile function on ex vivo resuscitation of isolated rat heart following one hour of hemorrhagic shock. Methodology: Sprague- Dawley rats were assigned to hemorrhage, hemorrhage + EIPA, sham hemorrhage and sham hemorrhage + EIPA groups. Rats were hemorrhaged for one hour. Hearts were harvested and ex vivo treated and resuscitated by perfused in the Langendorff System. Myocardial function was determined. Results: The results showed that inhibition of the Na+-H+ exchanger using EIPA improved the post-resuscitation myocardial contractile function. Conclusion: Blocking the Na+-H+ exchanger using 100mM EIPA following 60 minutes of hemorrhagic shock improved myocardial function.

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