Abdul Karim, Noorul Huda Ansari, Mushtaq Ahmad, Shafiq Iqbal, Abid Mehmood.
Amlodpine on lipid profile.
Professional Med J Jan ;11(4):437-41.

Now a days Calcium channel blockers and Beta blockers are widely used for the treatment of essential hypertension. Beta blockers have been observed to increase the serum cholesterol, serum triglycerides and serum LDL cholesterol levels, calcium channel blockers have been noted to have a beneficial effect on lipid profile. Setting: In outpatient clinic of Bahawal Victoria Hospital, Bahawalpur Period: From 1 Sep 2003 to 31 Mar 2004 (three months). st Material & Methods: Blood pressure, systolic and diastolic, and lipid profile (Serum cholesterol, LDL cholesterol, HDL cholesterol and serum triglycerides) were investigated in patients receiving Amlodipine therapy. This was a 3 months follow-up study, which was carried on 90 patients. The effects of drugs were assessed at various time intervals. Second generation Calcium channel blocker, Amlodipine, which is widely used for treatment of Hypertension was selected to observe its effect on serum lipid profile in various patients. Results: The mean systolic and diastolic blood pressure decreased from 158 mm Hg and 104.4 mm Hg to 122.26 mm Hg and 38.56 mm Hg respectively after 90 days of treatment with Amlodipine. The fall in serum cholesterol level (mg/dl) and LDL-cholesterol (mg/dl) was from 188.13 and 125.40 to 170.76 and 105.7 after respectively after 90 days. Conclusion: Amlodipine significantly reduced blood pressure, decreased the level of serum cholesterol and LDL cholesterol but did not affect significantly the HDL cholesterol and serum triglycerides.

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