Rakhshanda Nawaz, Asma Butt, Muhammad Nawaz.
Kinetics of diclofenac sodium.
Professional Med J Jan ;11(4):411-5.

The study was conducted to determine the pharmacokinetis of diclofenac in healthy male volunteers so as to establish therapeutic norms. Setting: Department of Chemistry, Physiology and Pharmacology University of Agriculture Faisalabad. Period: During the year 2003. Material & Methods: The concentrations of diclofenac sodium in the plasma of 10 male volunteers were determined by HPLC analysis following oral administration of 50 mg capsules. Results: The diclofenac molecule was found to absorb rapidly and the concentration was detectable even after 10 minutes of the drug intake. The mean±SD values for the absorption kinetic parameters were for max max time to peak concentration (T ) 0.53±0.05 hours (range 0.42 to 0.56 hours), C 2.52±0.17 mg/L (range 2.25 to 2.72 mg/L), absorption half-life 0.21±0.06 hours (range 0.08 to 0.28 hours) and the absorption rate constant (Ka) 3.77±1.75 1/h (range 1.75 to 8.16 1/h). The disposition kinetics parameters revealed mean±SD values for AUC 4.31±0.45 h . mg/L and ranged between 3.66 to 5.01 h. mg/L,c Volume of the Central Compartment (V ) 9.41±2.12 L range 7.08 to 12.79L, Volume of distribution 46.34±20.37 liter ranged 32.64 to 79.18L, distribution half-life 0.32 ± 0.10 hours range 0.19 to 0.47 hours and elimination half-life 2.80 ± 1.35 hours range 1.61 to 5.58 hours and the mean residence time (MRT) 1.94±2.62 hours range 1.86 to 3.87 hours. Conclusions: Variable parameters were observed for disposition kinetics of diclofenac in this pilot study indicating the need for dosage adjustment and its evaluation.

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