Zahid Askar, Mohammad Idrees, Israr Ahmad, Mohammad Ayaz Khan, Awal Hakeem, Noorul Iman.
Comparative disintegration profiles of generic copies of fosamax.
J Pak Orthop Assoc Jan ;21(1):33-7.

Objective: To compare the disintegration time of various generic forms of Alendronate sodium available in Pakistan with Fosamax. Study Design: In vitro comparative study Place and Duration of Study: Libra Pharmaceuticals, Hayatabad Industrial Estate Peshawar and Khyber Teaching Hospital, Peshawar from February 2006 to March 2006 Materials and Methods: The disintegration time of twelve tablets of each of the drug to be tested was measured using basket-rack method with USP water at 370 C. The time was noted in seconds and was analyzed statistically for distribution and significance. Results: There was no statistical significant difference between Fosamax, Drate and Reventa. There was statistical significant difference between Fosamax, Alendrate, Bongard and Osto. Conclusions: The in vitro disintegration time of Fosamax, Drate and Reventa show no significant difference.

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