Muhammad Sadik Memon, Shamsuddin Solangi, Fida Hussain Shaikh, Muhammad Aamir Ghori, Muhammad Kamran Ansari, Abdul Wali Dawoodpoto.
Clinical, serological and histological features of celiac disease in the adult population a tertiary care hospital experience.
Med Channel Jan ;16(2):223-223.

OBJECTIVE: To determine clinical & histological presentation of celiac disease at ISRA University Hospital Hyderabad. DESIGN: Cross sectional study PLACE & DURATION: ISRA University Hospital Hyderabad; from March, 2007 to February, 2008. METHODS: All consecutive patients full filling the inclusion criteria were enrolled in to this study. After consent a separate pro forma was filled for each case to record demography and data about clinical presentation and laboratory investigations. The diagnosis of celiac disease was made on the basis of the serological and histological features consistent with celiac disease. SAMPLING TECHNIQUE: Convenient sampling INCLUSION CRITERIA: The adult patients clinically suspected of celiac disease or had refractory iron deficiency anemia. EXCLUSION CRITERIA: The cases having clinical features suggestive of CD with normal serological tests; the cases with serological study consistent with CD but did not agree for carrying out duodenal biopsy and the cases of abdominal tuberculosis, giardiasis or chronic pancreatitis. RESULTS: Fifty cases full filled the inclusion criteria and were enrolled in to this study. Thirty (60.0%) were females and 20 (40.0%) males; mean age was 33.25 ± 9.7 years. Of 50 cases 44 (88.0%) presented with classic or typical features of celiac disease where as 6 (22.0%) presented with atypical features. CONCLUSION: The celiac disease is not uncommon in adult population of our country. It is more prevalent in females as reported elsewhere; majority of adult patients has typical gastrointestinal symptoms of disease. We assume that CD has been hitherto, underground in our country.

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