Ahmad Al Omari, Fares Haddad, Jennings P E.
Outcome of radioactive iodine treatment for hyperthyroidism. single centre experience.
Rawal Med J Jan ;35(1):61-4.

Objective: To determine the outcome of radioactive iodine (RAI131) treatment for hyperthyroidism at York District Hospital and to assess factors that affect the success of treatment. Patients and Methods: In this retrospective study, the medical records of all patients who received radioactive iodine treatment (RAI131) for hyperthyroidism at York District hospital between January 2000 and December 2004 were studied and analyzed in relation to age, gender, diagnosis, pretreatment with antithyroid drugs (ATD), the presence of antithyroid perioxidase antibodies (TPO) and dose of radioactive iodine. The effect of these variables on the outcome was assessed. Results: There were 282 patients. 76.6% were females with mean age of 54.4 years. 86.5% had Graves, disease and 83% were pretreated with antithyroid drugs. Antithyropeioxidase antibodies were tested in 161 patients, and 43.2% were positive. Mean dose of radioactive iodine was 421 MBq . At 6 months 81.1% of patients were cured and 64.2% were on Levothyroxin replacement. Severe hyperthyroidism and pretreatment with antithyroid drugs adversely affected the outcome; a higher radioactive iodine dose had a favorable effect, while gender and presence of TPO did not influence the outcome. Conclusion: Radioactive iodine (RAI131) is a safe and effective treatment for all forms of hyperthyroidism and can be used without prior treatment with antithyroid drugs. (Rawal Med J 2010;35:61-64.

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