Meh Jabeen, Muhammad Furqan, Nudrat Anwar Zuberi.
Relation of brain natriuretic peptide, mean arterial and pulse pressures among normotensive, pre-hypertensive and hypertensive male cohort.
J Dow Uni Health Sci Jan ;3(3):121-6.

Background: Hypertension is an increasingly important medical and public health issue. Individuals prone to the development of hypertension often have a hyperdynamic circulation antedating the onset of hypertension by several years. Brain Natriuretic Peptide is a new promising cardiovascular risk marker due to its association with high blood pressure via its mechanisms of secretion and actions. Both pulse and mean arterial pressures are independent markers of cardiovascular diseases. Objective:This study was designed to find out any relation between the rising values of pulse and mean arterial pressures among normotensives, pre-hypertensives and newly diagnosed hypertensives with the changes in plasma brain natriuretic peptide levels. Methods: This was an observational, analytical cross-sectional study conducted in department of physiology at Basic Medical Sciences Institute, Jinnah Post Graduate Medical Center, Karachi. Study included 85 adult males, aged between 20-60 years, non- smokers, non- diabetic and having no other chronic illnesses. Pulse and mean arterial pressure values were found. Study participants were divided into three groups ranging from normotensive to hypertensive stages, as stated by Joint National Committee -7. Brain Natriuretic Peptide was assayed by AxSym technology. Results: Brain Natriuretic Peptide developed a positive correlation with both pulse and mean arterial blood pressures and was also found out to be significantly raised in pre-hypertensive group. Conclusions:This study concluded that Brain Natriuretic Peptide is positively related with increasing values of both variables i.e. pulse as well as mean arterial blood pressures. It also concluded that Brain Natriuretic Peptide is significantly elevated in pre-hypertensive stage and is not very different from the levels seen in sustained hypertension.

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