Muhammad Farooq Alam Siddiqui, Fauzia Imtiaz, Rukhsana Rubeen, Mahayrukh Asif, Zeba Haq, Musarrat Nafees.
Effects of a-tocopherol on lipid profile in primary hyperlipidemia.
J Dow Uni Health Sci Jan ;2(3):91-6.

Objective: To determine the antihyperlipidemic effects of -tocopherol in primary hyperlipidemia. Design: An analytical cohort study Patients and Methods: This study was conducted in the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute of Jinnah Postgraduate Medical Center, Karachi, from February to April 2001. Newly diagnosed and un-treated primary hyperlipidemic persons of either gender between the ages 17 to 70 years were initially enrolled in the study for a 12 weeks (90 day) trial with fortnightly follow up visits. The selected patients were divided into 2 groups. The first group (Group-I) was treated with diet restriction and exercise only. The second group (Group-II) was treated with diet restriction, exercise and a-tocopherol. Results were compared using paired t-test. Results: There were 35 patients in all. After treatment with a-tocopherol, cholesterol reduction was highly significant (p<0.01). Triglyceride reduction was significant (p<0.05). Increase in HDL-c level was highly significant (p<0.001). The LDL-c reduction was statistically highly significant (p<0.001). VLDL reduction was also significant (p<0.01). When compared between the Groups I and II, the reduction in cholesterol was moderately significant (p<0.01), LDL-c reduction was found to be markedly significant (p<0.01). HDL and VLDL reduction was also found to be significant (p<0.05). In comparison there was no significant change in triglyceride level. Conclusion: Diet restriction and exercise had significant beneficial effects on lipid profile. When supplemented with a-tocopherol, there was a highly significant beneficial effect on lipid profile. Keywords: Lipid Profile, a-Tocopherol, exercise, diet

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com