Ghodrat Mohammadi, Shabnam Hajali.
Elective nodal irradiation after total laryngectomy in T3n0 supraglottic squamous cell carcinoma.
Rawal Med J Jan ;35(2):192-3.

Objective: To evaluate patients who received bilateral elective nodal irradiation (ENl) alone as a sole treatment to clinically negative neck. Method: We retrospectively reviewed clinical records of 55 T3N0 supraglottic squamous cell carcinoma (SCC) patients with cord fixation treated in Imam Hospital, Tabriz from January 2001 to January 2007. The primary site was treated with laryngectomy and radiotherapy (RT), and their NO necks were treated with RT alone. RT was delivered in standard fractionation and field arrangement with median dose of 5000 cGy. Results: Out of fifty five patients, six were excluded because of the preoperative treatment with chemotherapy and/or radiation, or positive margins. Four had insufficient follow up, leaving 45 patients with N0 necks who completed radiation in both side. On median follow up of 24 months, the clinically negative neck was the first site of failure in 4.4% of patients (2/45). Median time to recurrence was 11 months. Conclusions: Our data support the use of ENI as a prophylactic treatment for clinically negative neck in T3 supraglottic SCC. We suggest that routine neck dissection may not be necessary, and ENI may be a safer modality is an oncologically acceptable alternative in T3N0 supraglottie SCC patients. Prospective trials are necessary to further define role of RT in this patient population. (Rawal Med J 2010;35:192-193).

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com