Shah Murad, Manzoor Ahmed Unar, Ghazi Mahmood, Samina Arim, Moosa Khan, Amar Lal Ghurbakhshani.
Placebo controlled study of psyllium husk to increase HDL cholesterol.
Rawal Med J Jan ;35(2):149-51.

Objective: To examine the effects of Psyllium husk on HDLCholesterol levels. Patient and Methods: This single blind placebo controlled study was conducted at Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2006 to July 2006. Forty hyperlipidemic patients were included with 20 serving as control and 20 as treatment group who were given Psyllium husk, 9 gram daily, in divided doses for the period of three months. Patients with peptic ulcer, renal disease, hepatic disease, hypothyroidism, diabetes mellitus, and alcoholism were excluded from the study. HDL cholesterol was determined by using a commercial kit (Eli Tech Diagnostic, France). Data were expressed as the mean±SD and "t" test was applied to determine statistical significance. Results: Two patients were dropped from the study due to low compliance of metallic taste of psyllium husk. Psyllium husk increased HDL cholesterol in 90 days of treatment from 34.61±1.85 to 36.77±1.96 (mg/dl), which was highly significant statistically. Percentage change was 6.24%. Conclusions: Psyllium husk increased HDL cholesterol by 6% after 90days treatment. (Rawal Med J 2010;35:149-151).

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