Ayisha Qureshi, Nadeem Afraz, Naseem Ashraf, Anjum A Siddiq.
Pregnancy rate and live birth rate are higher after blastocyst transfer than after day 2 and day 3 embryo transfer following Intracytoplasmic sperm injection (ICSI).
Rawal Med J Jan ;35(2):124-8.

Objective: To compare the differences in outcome when embryo transfer was performed on day 2, day 3 and day 5 following ICSI. Method: A total of 644 subjects undergoing ICSI at Islamabad Clinic Serving Infertile Couples, with embryo transfers on day 2, day 3 and day 5 were included. It was carried out between February 2000 and February 2005. Main outcomes measured were fertilization, pregnancy and live birth rates. Results: The percentage of Metaphase II oocytes retrieved and the fertilization rate were significantly (P<0.001) higher in blastocyst transfer subjects. Day 5 transfer subjects were observed with significantly (P<0.01) higher number of grade I embryos as compared to day 2 and day 3 embryo transfers. The mean number of embryos transferred was not significantly different in cleavage stage (day 2 and day 3) and blastocyst stage (day 5) embryo transfers. The cumulative pregnancy rate per embryo transfer and live birth rate were higher in blastocyst stage subjects (51.3% and 39.6%), as compared to day 2 (42.5% and 19.9%) and day 3 (37.6% and 33.4%) embryo transfers. Conclusions: Our data suggests that blastocyst transfer has a higher pregnancy rate with a higher live birth rate. (Rawal Med J 2010;35:124-128).

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