Zulfiqar Ali Rana, Muhammad Waqar Rabbani, Muhammad Aslam Sheikh, Imran Iqbal.
Clinical, histopathological and immunological profile of hodgkin lymphoma at the children hospital & the institute of child health multan.
Pak Paed J Jan ;34(4):194-7.

Objective: To describe the clinical presentation, histopathological types and immunological profile of Hodgkin lymphoma at The Children Hospital & the Institute of Child Health Multan. Study Design: Descriptive Study Place & Duration of the Study: Pediatric Oncology Department, The Children Hospital & the Institute of Child Health Multan. From January, 2006 to November 2010. Patients & Methods: All the newly diagnosed children with Hodgkin lymphoma =15 year age were included in the study. Diagnosis was based on history, local examination of the lymph nodes, lymph node biopsy for histopathology & immunohistochemical staining. Chest X-Ray, CT scan of the abdomen, bone scan and bone marrow biopsy were done for staging. Results: Among 32 children with Hodgkin lymphoma, 29 (91%) were males with M: F =9.7: 1. Age of presentation was 3.5-15 years with Mean age of 8.6 years. Cervical lymphadenopathy was present in 27 (84%) & Mediastinal lymphadenopathy in 4(12%) patients. Stage I, II, III&IV was found in 9(28%), 3(9%), 18(56%) & 2(6%) patients respectively. Mixed cellularity (MC) was the most common histopathological type, found in 25 (78%) patients, followed by nodular sclerosis (NS) in 6(19%) & lymphocyte predominant (LP) in 1(3%). On Immunohistochemical staining, CD 30 was positive in all patients. Conclusion: Pediatric Hodgkin lymphoma is more common in males and presents at a younger age. Cervical lymphadenopthy is the most common clinical presentation and mixed cellularity, the most common histopathological type with CD 30 positivity in all patients.

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