Khalida Khanum, Maimoona Naheed, Nelofer Sultana, Riffat Mahmood, Saeed Anwar, Nasreen Javaid, Razia Iftikhar.
Comparative nephrotoxic effects of gentamycin and tobramycin.
J Surg Pak Jan ;16(1):28-32.

Objective To compare the nephrotoxic effects of two aminoglycosides namely, gentamycin and tobramycin on rabbits. Study design Comparative study. Place & Duration of study Allama Iqbal Medical College Lahore, from January 2010 to December 2010. Methodology The serum levels of creatinine and electrolytes (sodium and potassium) were measured in different groups of rabbits (control group-A, gentamycin group B and tobramycin-group C). Rabbits in group B and C received laboratory diet and 32 mg/kg/day of gentamycin and tobramycin were given through intramuscular (IM) route twice daily for 7 days. Blood samples were collected on day 1, 10, 16, and 22 of drug administration. Each rabbit of all groups was sacrificed on 22nd day of experiment. Kidneys were removed and histological examination of the 4 components of the renal tissue (glomeruli, tubules, blood vessels and interstitial tissue) was carried out. Results Level of serum creatinine was significantly increased in both experimental groups (B and C) as compared to the control group A. On the other hand, level of serum sodium was insignificantly increased in groups B and C, whereas level of serum potassium was ignificantly decreased in groups of rabbits receiving gentamycin and tobramycin as compared to control group. Conclusions There was no significant difference in nephrotoxicity between gentamycin and tobramycin.

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