Naila Ambreen, Shagufta Yasmeen, Angela Emanuel, Syeda Batool Mazhar.
Glanzmann's thrombasthenia.
Ann Pak Inst Med Sci Jan ;7(2):47-9.

Glanzmann\'s thrombasthenia (GT) is a rare congenital bleeding disorder. It is characterized by deficiency or defect of the fibrinogen receptor (GPIIb/IIIa) resulting in defective platelet aggregation. Patients usually present with mucocutaneous bleeding, and menorrhagia and excessive bleeding associated with trauma and/or surgery. Patients have an increased bleeding time and a normal platelet count with abnormal platelet function assays. Platelet transfusion is considered the standard therapy for securing hemostasis. We report a case of Glanzmann’s thrombasthenia who presented with menorrhagia since menarche. After medical treatment for 15 years and failure to respond since seven years, transabdominal hysterectomy was done as a last resort.

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