Mian Iftikharul Haq, Musarrat Hussain, Ikram Ullah, Zafar Iqbal.
Frequency of carcinoma in cholecystectomies performed for symptomatic gall stones.
Ann Pak Inst Med Sci Jan ;7(2):75-8.

Objective: To find out the frequency of gallbladder carcinoma in cholecystectomy specimens removed for symptomatic gallbladder stones. Study Design: Case series Place and duration: This study was carried out in surgical “A” ward, Lady Reading Hospital Peshawar, from 1st Jan 2006 to 31st March 2008. Materials and Methods: All adult patients of either gender who presented to surgical OPD with symptomatic gall stones disease were included in the study. Informed consent was taken. Initial assessment was done with history, clinically examination and relevant investigations. All these patients underwent cholesystectomy through right subcostal incision and their gallbladder specimens were subjected to histopathology. Results: One hundred and seven patients underwent cholecystectomy for gallbstones. Of them 5 (4.67%) cases turned out to be gallbladder adenocarcinoma. In our study, the maximum number of patients, 3 (60%), were in the age group of 51 to 60 years. The remaining two patients had ages of 48 years and 69 years respectively. The mean age was 58.5 years. In this study, out of 5 patients with adenocarcinoma of the gallbladder four (80%) were females and one (20%) was male. Using TNM staging three (60%) patient were in stage I and two (40%) patients had stage II disease. Conclusion: Carcinoma gallbladder is often unexpectedly discovered in cholecystectomy specimens removed for benign gallbladder disease, therefore histopathological examination of every removed gallbladder specimen should be routinely performed.

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