Muhammad Humayun, Ambreen Khalid, Azam Ali, Shakeel Ahamad, Atif Javed.
To study the levels of serum chromium, copper, magnesium and zinc in patients with diabetes mellitus type 2.
Pak J Med Health Sci Jan ;5(2):368-72.

Objective: To study the correlation of trace elements deficiency with diabetes Mellitus. Study design: This is a prospective, cross sectional and comparative study. Settings: The study was conducted at diabetes management center of Jinnah hospital. Material and Methods: A total of 100 subjects were selected, 50 were diagnosed patients of diabetes type 2 and 50 were normal healthy individuals. . The study was conducted at diabetes management center of Jinnah hospital and normal healthy individuals were selected from relatives of the patients. It was a continuous study and the required samples were collected form the diabetic patients and normal healthy individuals over a period of two months, from January to February2011. Plasma glucose level was estimated by using glucose oxidase method. The modified colorimetric procedure of Fluckiger and Winterhalter was employed for estimating HbA1c levels. Serum trace elements were estimated by atomic absorption spectrophotometer. Results: The mean fasting blood glucose level in Diabetics was significantly greater (151.38±37.970) mg/dl than in Non Diabetics healthy controls (88.320±9.707mg/dl). Mean HbA1-c level in case of Diabetics was significantly greater (7.470±1.183gm%) than Non Diabetic healthy controls (5.664±0.0747mg%). No statistically significant difference (P value is >0.05) in the mean Cu++ level was observed between Diabetics ( 88.4±40 µ g/dl) and in normal healthy controls ( 101±39 µ g/dl ) . Serum Zn was significantly lesser (P value <0.05) in Diabetics (510±89 µ g/dl) than in Non Diabetics(603±91µ g/dl). Similarly serum chromium level was significantly lesser in Diabetics (1.99±0.8 µ g/dl) than in normal healthy controls( 2.61±0.054 µ g/dl). Mean serum level of Mg++ was significantly lesser (P value is <0.05) in Diabetics (17.76± 0.66 µ g/dl) than in normal healthy controls (22.13±1.65 µ g/dl). Conclusion: In the present study serum chromium, zinc and magnesium were found to be significantly lower in patients with diabetes type 2 as compared to normal healthy individuals. Serum copper was also low but it was not statistically significant

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