Muhammad Asif Qureshi, Shams Nadeem Alam.
Oncogenic viruses: a review of epithelial mesenchymal transition (EMT) as a metastatic tool in viral induced cancers.
Rawal Med J Jan ;36(4):316-20.

Objecive: To summarize current knowledge on induction of Epithelial-Mesenchymal-Transition (EMT) during viral oncogenesis. Methods: Publications describing “induction of EMT in viral induced cancers” were retrieved from Pubmed database and managed in the End Note software (version XIII) for further analysis. Results: Some oncogenic viruses like EBV, HPV, HBV, HCV, and adenoviruses have recently been shown to switch on the EMT-programming prior to tumor invasion. Various proteins involved in viral induced EMT include TGFß, NFkB, Smad3, Cadherins, Catenins and Hbx, amongst others. Conclusion: Epithelial-Mesenchymal-Transition has been involved as metastatic tool by oncogenic viruses. We recommend further research on the topic to fill the existing gaps.

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