Adnan Asaad Abu Omar, Khaled Awwad Al Issa.
Intravenous paracetamol (perfalgan) for analgesia after cesarean section: a double-blind randomized controlled study.
Rawal Med J Jan ;36(4):269-73.

Objective: To evaluate the analgesic efficacy of intravenous paracetamol (Perfalgan) for pain control after cesarean delivery. Patients and Methods: This prospective, double-blind, randomized, placebo-controlled study was performed on eighty ASA I-II women who had elective cesarean sections under spinal anesthesia with spinal morphine. Patients were randomly divided into two equal groups by a table of randomization. Forty patients received (1g/100ml) intravenous paracetamol (group I) at the end of surgery and every 6 hours for 24 hours and 40 patients received 100ml normal saline as placebo (group II) at the stated time. Standard analgesia meperidine (pethidine) was available as a rescue drug to both groups. The number of patients who required rescue analgesic drug, pain scores and satisfaction of patients were evaluated for 24 hours postoperatively. 2 Results: In the group I, no patients required rescue drug compared to 25% in the group II (P<0.05). Median pain scores were less in the group I at 6 hours [1(range 1-6) vs. 3 (range 1-8), p = 0.002] at 12 hours [2 (range 0-5) vs. 3 (range 0-7), p = 0.031] and at 24 hours [1.5 (range 0-4) vs. 3 (range 1-8), p< 0.0001], respectively. Satisfaction was comparable in both groups. Conclusion: We conclude that Intravenous paracetamol is an effective treatment option and can be used to reduce the requirement of rescue opioid drugs for pain control after cesarean section.

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