Zafar Htanveer, Rahim Khan M Ibrahim, Khurram Munir, Aftab Ahmad, Sj Khan.
Is increased erythrocyte lithium sodium counter transport a useful marker for essential hypertension?.
J Sheikh Zayed Med Coll Jan ;2(2):171-3.

The pathogenesis of essential hypertension needs to be determined. Objective: To compare the rate of sodium counter transport in mild and moderate essential hypertensives with normotensive subjects. Subjects and Methods: The study was conducted on age and sex matched 20 mild essential hypertensives (G2), 20 moderate essential hypertensives (G3) and 20 normotensives (G1). All cases were diagnosed after taking detailed history, complete physical examination and laboratory investigations. Lithium efflux and maximum rate (Vmax) of Lithium-Sodium countertransport was measured in red blood cells. Results: Increase in Lithium efflux and Vmax of Lithium- Sodium counter transport of mild and moderate essential hypertensives was highly significant (p<0.001)than that of normotensives. Conclusions: Lithium efflux and Vmax of sodium coutertransport is raised in mild and moderate essential hypertensive as compared to those in normotensive subjects. This can be used as a marker for the diagnosis of essential hypertension.

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