Shameem Ahmad Siddiqui, Saira Bashir, Iffat Shabbir, Misbahul Islam Khan Sherwani, Muhammad Aasim.
Association of insulin resistance with obesity in children.
Pak J Med Res Jan ;50(4):137-40.

Background: Insulin resistance is the primary metabolic disorder associated with obesity. Little is known about its role as a determinant of the metabolic syndrome in obese children. Objectives:To assess the association of insulin resistance with metabolic syndrome in obese and non obese children. Study type and settings: Cross sectional analytical study conducted among children of ten Municipal Corporation high schools of Data Ganj Buksh Town Lahore. Subjects and Methods: A total of 46 obese and 49 non obese children with consent were recruited for the study. Fasting blood glucose, serum insulin, high density lipoprotein cholesterol, triglycerides, cholesterol, non HDL-cholesterol LDLcholesterol were measured using standard methods. Data were analyzed by using statistical software SPSS-Version 15. Results: A total of 95 children 49 obese and 46 non obese were recruited for the study. A significant association of serum triglyceride (p<0.001), high density lipoprotein cholesterol (p<0.001), fasting blood glucose (p<0.001), and insulin levels (p<0.001), was seen between the two groups. For each component of metabolic syndrome, when insulin resistance increased so did odds ratios for cardio metabolic risk factors. Conclusions: Insulin resistance was seen in 34.7% children. Metabolic syndrome was found in 31.6% children reflecting that obese children are at high risk for metabolic syndrome and have low HDL-cholesterol and high triglycerides levels. Policy message: Obesity in children should be taken seriously by both parents and teachers with counseling for consulting experts to tackle this disease in early stages of disease.

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