Isam Hamo Mahmood, Hanaan Jadaan Ali.
Effects of hormonal contraceptives on prevalence of metabolic syndrome in women.
Rawal Med J Jan ;37(2):199-202.

Objective: To investigate the effects of hormonal contraceptives on the prevalence of metabolic syndrome in women. Methods: The study was conducted on 94 women who used hormonal contraceptives. They were divided into two groups: Group one consisted of 43 women who used depot medroxyprogesterone acetate and Group 2 consisted of 51 women who used oral combined contraceptive. Another group had 70 apparently healthy women, not on hormonal contraceptive, as control. Diagnosis of metabolic syndrome was based on criteria recommended by the US National Cholesterol Education Program Adult Treatment Panel III. Waist circumference (WC), serum glucose, serum triglycerides, total cholesterol and HDL cholesterol were measured. LDL- cholesterol was determined by Friedwald equation. Results: Metabolic syndrome was seen in the contraceptive users but not in controls. All measured parameters were higher in the contraceptive users in comparison with non contraceptive users except for HDL-cholesterol which showed lower values in the contraceptive users and glucose concentrations in the oral contraceptive users which showed no significant difference with that of non contraceptive users. Conclusions: The hormonal contraceptives can induce metabolic syndrome in women who used it by their effects on BP, WC, body weight, lipid profile and serum glucose concentration. (Rawal Med J 2012;37:199-202).

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