Amjad Ali, Khan Muhammad Babar.
Comparison of preoperative dose of pregabalin with celecoxib for attenuation of postoperative pain after open cholecystectomy.
Anesth Pain Intens Care Jan ;16(2):137-41.

Objective: To evaluate the efficacy of a single preoperative dose of pregabalin in comparison to celecoxib for attenuating postoperative pain after open cholecystectomy. Setup: Department of Anaesthesiology, Bolan Medical Complex Hospital, Quetta. Design: Randomized, controlled trial. Methodology: Sixty adult patients, 35–65 years of age, ASA physical status I or II, of either sex, undergoing elective open cholecystectomy were allocated randomly in this prospective, randomized, controlled study. Patients were randomly divided into two groups of 30 each, to receive either pregabalin 150 mg or celecoxib 200 orally 1 hour before surgery. Postoperative pain was assessed by a 10cm visual analogue scale, where 0 denoted no pain and 10 was taken as the worst imaginable pain. Sedation, postoperative nausea and/or vomiting and any other complication, were assessed periodically throughout the study time. Patients received inj. nalbuphine on demand during the postoperative period and nausea and vomiting were treated with metocloperamide 10 mg. Results were statistically analysed. Results: Cumulative consumption of inj. nalbuphine over 24 hours was 13.5 ± 7.4 mg for pregabalin group, and 13 ±6.7mg for celecoxib group (P >0.05). No significant difference was found in frequency and severity of postoperative nausea and vomiting (PONV) during 24 hours (P > 0.05), although frequency of sedation was higher in pregabline group (P <0.05). Conclusion: Preoperative single dose of pregabalin 150 mg provides no better pain relief when compared to celecoxib 200 mg, and high incidence of adverse effects were found in patients receiving pregabline before open cholycystectomy.

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