Shireen Ramzanali Damani, Sughra Perveen, Syed Sagheer Hussain Shah.
Phyllodes tumors of breast: a review of 30 cases.
J Surg Pak Jan ;17(3):126-9.

Objective: To describe clinical features, histopathology, treatment and prognosis of phyllodes tumor of breast. Study design: Descriptive case series. Place & Duration of study: Department of Surgery, Jinnah Postgraduate Medical Centre Karachi, from 2005 to 2011. Methodology: This is a retrospective review of the medical records of patients managed over a period of six years. The data of patients with phyllodes tumor (PT) of breast were analyzed for age at the time of diagnosis, the duration of the illness, tumor size, tumor localization, ultrasound features, preoperative diagnosis, surgical procedure, pathological grading and outcome. Grading of tumor was done according to the World Health Organization (WHO) classification. Results: The age of the patients ranged from 19 year to 66 year (mean age 40 year). The mean age of occurrence of benign, borderline and malignant tumors was 35.5, 44.5 and 45.6 year respectively. The mean time from onset of symptoms and pathological diagnosis of PT ranged from one to 36 months (mean 15 months). Tumors occurred in the left breast in 12 cases, and on right side in 16 cases. The upper outer quadrant was involved in 11 (36.6%) cases. The resection margin was recorded as negative in 18 cases. Nine patients underwent postoperative radiation (3 borderline and 6 malignant PTs). Local recurrence occurred in one benign, 3 borderline and 2 malignant cases. Treatment in the case of recurrent benign PT included lumpectomy. Mastectomy was done in 5 other recurrent cases. Conclusions: Phyllodes tumors of the breast have an unpredictable outcome. A wide local excision, with adequate margin of normal breast tissue, is the preferred initial therapy.

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