Muhammad Kashif Baig, Iram Irshad, Faiza Naseer.
Caesalpinia decapetala hepatoprotective activity of ethanol extract.
Professional Med J Jan ;20(3):478-84.

Members of genus Caesalpinia are found world widely in tropical and temperate areas. Caesalpinia species have various pharmacological actions that include antidiabetic, antiulcer, anticancer, anti-inflammatory, antimicrobial and antirheumatic. Objectives: To assess the Hepatoprotective activity of ethanol extract of Caesalpinia decapetala. Duration of study: September 2012 to November 2012. Setting: Pharmacology and Pathology departments of Independent medical college and animal House of university of agriculture, Faisalabad. Study design: Experimental study. Materials and Methods: Hepatoprotective activity was determined by measuring the liver marker enzymes like Bilirubin, AST, ALT and ALK levels and then hepatic biopsy to see any structural changes. Phytochemical analysis of plant extract indicates that it contains polyphenols and flavonoids that possess antioxidant potential and hence possess Hepatoprotective activity. Results: Liver enzyme levels were significantly raised in rabbits receiving paracetamol and the enzyme levels were significantly reduced in rabbits who were receiving Caesalpinia Decapetala and paracetamol comparable to silymarin and Paracetamol. Results observation was done in concentration and dose dependent manner. Histopathological studies indicated centrizonal and focal necrosis and ballooning in liver of rabbits treated with paracetamol. It showed only mild steatosis with sinusoidal dilatation and binucleate cells in groups receiving Caesalpinia decapetala. Conclusions: It is concluded that Caesalpinia decapetala possesses significant Hepatoprotective activity.

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