Humayun Rashid, Qazi Tufail, Tahir Shafi.
Role of N- acetylcysteine in prevention of contrast induced nephropathy.
Pak J Med Health Sci Jan ;5(4):735-7.

Objective: To determine the role of N-acetylcysteine in the prevention of CIN in high risk patients who underwent coronary angiography Study design: Retrospective, observational study. Methods: Medical records of 120 patients of both gender and age >30years who underwent coronary angiography, were reviewed from January 2010 to November 2010. All these patients divided into two groups. Group A received N-acetylcysteine and Group B patients did not received N-acetylcysteine. Acute contrast induced nephropathy was defined as an increase in the serum creatinine concentration of at least 0.5mg/dl from base line upto 48 hours after administration of contrast agent. All data was collected on a predesigned proforma. Age was compared between two groups by independent t test and others parameters were analyzed by Chi-square test. Results: There was statistically significant difference between two groups (non N-acetylsysteine group17% and N-acetylcysteine group 3%,p=0.029). Conclusion: Iopromidol, a non ionic, low osmolality contrast agent can induce acute contrast induced nephropathy in high risk patients which can be prevented by prophylactic oral administration of the antioxidant N-acetylcysteine, keeping all patients well hyrated/euvolemic.

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