Musrat Akhtar, Naheed Fatima, Salma Jabeen, Muhammad Akram.
Role of progesterone in the management of threatened miscarriage.
Pak J Med Health Sci Jan ;6(1):261-4.

Objective: To find out the efficacy of Progesterone in the management of threatened miscarriage. Study design: A Quasi Experimental study. Duration & settings of study: The study was conducted in the Department of Obstetrics & Gynaecology, Bahawal Victoria Hospital, Bahawalpur from 01-1-2010 to 31-12-2010. Materials & methods: A Total of 60 patients admitted with threatened miscarriage at gestational age 5-14 weeks having viable pregnancy were studied. The diagnosis was made on history, examination and viability was confirmed on ultrasonography. Patients were divided into two groups; A and B. Group-A was given Progesterone & Group-B was given no treatment, only the bed rest was advised to patients of Group B .It was observed whether the vaginal bleeding stopped, abdominal discomfort/pain settled and pregnancy continued to second trimester or not. Results: Basic parameters such as age, BMI, gravidity and period of gestation at the start of treatment did not differ between the two groups. Vaginal bleeding settled in Group-A in 16 (53.33%) and in Group-B 12(40%) patients. Abdominal pain / discomfort settled in Group-A 15(50%) of the patients and in Group B 12(40%). The most important variable was persistence of pregnancy up to 2nd trimester. Group-A showed persistence of pregnancy up to 2nd trimester in 16(53.3%) and in Group-B 11(36.7%). Conclusion: The use of progesterone in the management of threatened miscarriage improves the outcome to some extent but not significantly.

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