Saira Bashir, Rabia Nadeem, Nauman Rauf Khan, Bilquis A Suleman, Ghulam Rasul Qureshi.
Histopathological analysis of 1000 colorectal biopsies in two years in Shaikh Zayed hospital, Lahore.
Pak J Med Health Sci Jan ;6(1):115-7.

Objectives: To document and analyse the histopathological changes in the colorectal biopsies from September, 2004 to September, 2006. Materials and methods: One thousand endoscopic colorectal biopsies were received from the Gastroenterology unit of Shaikh Zayed Hospital, Lahore. These biopsies were examined by routine histopathology methods. Results: A higher frequency of colonic disease in males with a male to female ratio of 1.1:1 and age range of 1.50 months to 80 years was observed. Histopathological analysis revealed mostly non-specific colitis (38.3%), followed by ulcerative colitis (11.8%), polyps (4.6%), colonic carcinoma (2.6%), solitary rectal ulcers (1.1%), infectious colitis including granulomatous, amoebic and fungal (0.7%). Miscellaneous lesions; melanosis coli, colonic aganglionosis and pseudomembranous colitis were also observed (0.9%). Conclusions: The most prevalent lesion in this series was non-specific colitis (mild, moderate, severe) followed by ulcerative colitis, polyps and carcinomas. This histopathological analysis of colorectal biopsy is an essential tool for diagnosis and confirmation of clinically suspected cases and before proceeding to major treatment plans.

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