Ayub Latif Khawaja, Khurram Saleem, Israr Ahmad, Usman Mohsin.
A Health Outcome Appraisal based on Quality of Life Measures in Patients of Gastroesophageal Reflux Disorder Receiving Treatment with a Proton Pump Inhibitor and a Prokinetic Agent.
Pak J Med Health Sci Jan ;6(3):789-93.

Objectives: We analyzed whether lifestyle modification involving dietary restrictions, exercise, quitting smoking, loosing weight, etc has a meaningful impact on health care outcome of patients with gastroesophageal reflux disorder (GERD) receiving treatment with pantoprazole and Itopride Hydrochloride as a post hoc analysis of an observational study that investigated the effect of pantoprazole and itopride on QOL Methods: Patients with GERD received pantoprazole and itopride for 8 weeks. Health-Related Quality of Life (HRQOL) was assessed using the 8-Item Short-Form Health Survey (SF-8) and GERD-specific QOL questionnaires at baseline and after 4 and 8 weeks of treatment. Physical and mental component summaries (PCS, MCS) and GERD-specific summary (GERDS) scores were calculated. Results: Of the 187 patients analyzed, 40.8% were advised regarding new lifestyle at the start of pantoprazole/itopride treatment (Group A), 33.3% were advised to continue the lifestyle as advised previously (Group B), and 25.9 % did not receive any advice (Group C). The change in PCS from baseline at week 8 for Group A was 5.7±8.1, and this was significantly greater (P<0.001) than the increases achieved in Groups B (4.3±7.5) and C (4.0±7.6). The changes in MCS and GERDS were also significantly greater in Group A than in the other groups. The changes in QOLS from baseline were significantly greater in Group A than in the other groups, irrespective of baseline pt characteristics. Conclusions: Lifestyle modification may be clinically beneficial in terms of improving QOL in a segment of Pakistani patients with GERD who are receiving treatment with a PPI.

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