Muhammad Anis Alam, Syed Muhammad Shamim, Syed Muhammad Masood Ali, Sayyada Humaira Masood.
Studies to evaluate the effect of Seeds of Mirabilis Jalapa on Blood Clotting and Bleeding time in Rabbit.
Pak J Med Health Sci Jan ;6(3):637-9.

Objectives: Mirabilis Jalapa belongs to the family nyctaginaceae. It is cultivated in West Indies and India. It has five varieties. Red and yellow flowers were introduced from the West Indies in 1596. Shortly afterwards it was introduced to Persia in the reign of Shah Abbas and was named Gul-e-Abbas. Method: The study was performed to find out its efficacy in bleeding and clotting time. For this purpose three groups of rabbits were made, one control, 2nd test group with low dose, 3rd test group with high dose. The study period was 60 days. Results: Result showed of clotting and bleeding time, PT (Prothrombin time) in control group was 9.0±0.29 seconds, in test group with low dose it was 9.2±0.32 and with high dose it was 8.7±0.24 with P value 0.396. APTT (Activated partial thromboplastim time. It was 25.2±0.46 seconds in control group and in test group it was with low dose 26.9±0.65 with high dose it was 23.4±0.65 with P value 0.002. BT (Bleeding time) it was 95.6±3.17 seconds in control group, it was 88.9±1.62 with low dose and it was 79.1±2.03 seconds with high dose with P value 0.001. CT (Clotting time) it was 103.9±5.12 seconds in control group it was 121.7±7.02 with low dose. It was 115.0±5.46 seconds with high dose with P value 0.122 (Table 2). During the study period of 60 days, no animal died and no animal behaved abnormally. The herbal drug mirabilis Jalapa is effective in blood disorders leading to certain diseases causing bleeding. However further studies are recommended.

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