Muhammad Amer, Shahab Uddin, Furukh Rasheed.
Comparison of Use of Metoclopramide Alone and in Combination with Dexamethasone for Prevention of Post Operative Nausea and Vomiting in Laparoscopic Cholecystectomy.
Pak J Med Health Sci Jan ;6(3):626-8.

Objective: To compare the efficacy of intravenous metoclopramide alone and in combination with dexamethasone for preventing nausea and vomiting (PONV) in the postoperative period in patients undergoing laparoscopic cholecystectomy. Study design: Single blinded, randomized, interventional study. Place and duration of study: This study was conducted in the department of Anesthesiology Bahawal Victoria Hospital Bahawalpur from May 2010 to May 2011. Patients and methods: After the approval from the ethical committee of the hospital, the study was conducted on 100 patients who were randomly divided into two groups A and B, each group containing 50 patients. All belonged to 25-40 years of age and A.S.A-I. Randomization was done by envelope draw method. The patients received metoclopramide 10mg alone or metoclopramide 5mg plus dexamethasone 4mg IV, 30 minutes before the induction of anesthesia. All the patients were given general anesthesia with endotracheal intubation using thiopentone sodium, succinylcholine and maintained with isoflurane and N2O with O2 in both groups. PONV were evaluated postoperatively. Results: Significantly less nausea and vomiting was noted in the first 24 h after surgery, in the patients of group B who received metoclopramide plus dexamethasone as compared to the patients in group A who received only metoclopramide Conclusion: In this study, a single dose of metoclopramide 5mg plus dexamethasone 4 mg produced better antiemetic effects after laparoscopic cholecystectomy than metoclopramide 10 mg alone.

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