Ashraf Zia, Sonia K Niazi, Razia Ashraf, Taifurul Islam Gilani.
Effect of Preoperative Gabapentin on Haemodynamic Response to Laryngoscopy and Tracheal Intubation in Patients Undergoing Any Elective Surgery.
Pak J Med Health Sci Jan ;6(4):1003-5.

Objective: To determine the effect of 800 mg oral gabapentin on haemodynamic response to laryngoscopy and tracheal intubation. Study Design: Randomized controlled trial. Setting: Services Hospital, Lahore, which is a tertiary care hospital, where almost all types of surgeries are performed. Duration: The study was completed in 6 months (21 sep 2011 to 20th march 2012) Sample Size: Total 110 patients were taken, which were divided into two equal groups. Method: Group G patients received 800 mg oral gabapentin while Group C patients received placebo capsules two hour prior to surgery in the pre operative area. After induction of anaesthesia heart rate, systolic, diastolic and mean arterial blood pressures were recorded at baseline and then 1 minute after intubation. Results: Out of total 110 patients there were 66 (60 %) males and 44 (40 %) females. Mean age was 37.1 in Group G and 36.3 in Group C. Overall there was less haemodynamic response in Group G as compared to the Group C. Group G had statistically significant decrease in mean heart rate, systolic and diastolic blood pressure at 1 minute post intubation. Conclusion: Gabapentin significantly reduces haemodynamic response to laryngoscopy and intubation.

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