Mohammad Nadeem.
Mantle cell lymphoma with leishmaniasis: a rare association.
J Rawal Med Coll Jan ;17(1):150-2.

Mantle cell lymphoma (MCL) is a B-cell NHL. Previously it was referred as intermediate lymphocytic lymphoma, centrocytic lymphoma, mantle zone lymphoma and lymphocytic lymphoma of intermediate differentiation. 1 Malignant transformation takes place in the outer edge of a lymph node follicle, called the mantle zone. MCL occurs more frequently in older adults – the average age at diagnosis is the mid-60s. It usually begins with lymph node enlargement and can spread to other tissues such as the marrow, liver, gastrointestinal tract and central nervous system.The peculiar characteristic of this lymphoma is its clinical course which combines the worst features of aggressive lymphomas (i.e aggressive course) and the indolent lymphomas (i.e frequent recurrences). It comprises about 7% of adult Non-Hodgkin’s lymphomas (NHL). 2 Leishmaniasis is a vector-borne protozoan infection spread by the bite of the female sandfly (Phlebotomus and Lutzomyia species). It is caused by protozoal parasites belonging to genus leishmania.3 It has a varied spectrum of clinical manifestations which can be divided into cutaneous leishmaniasis, mucosal leishmaniasis and visceral leishmaniasis (Kala Azar). The mortality of untreated Visceral Leishmaniasis is 75–95% and is endemic in 88 countries largely located in the tropics and subtropics. 4 We report one such case.

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