Abbas Ali Tasneem, Sabahat Sarfaraz, Syed Mujahid Hassan, Nasir Hassan Luck, Sabiha Anis, Zaigham Abbas.
Job�s syndrome with an atypical presentation.
J Pak Med Assoc Jan ;63(11):1427-9.

Hyper Immunoglobulin E syndrome also called Job\'s or Buckley Syndrome is a rare primary immunodeficiency disease characterized by elevated serum IgE levels (>2000 IU/ml), recurrent infections and eosinophilia. Other features include coarse facies and non-immunologic abnormalities of the dentition, bones, vasculature and connective tissues. We are reporting a case of a twenty four years old male with coarse facies who presented with severe pallor and upper gastrointestinal bleeding. Investigations revealed markedly elevated serum IgE levels (11,800 IU/ml), severe anaemia, esophageo-duodenal erosions, Helicobacter pylori (H. pylori) gastritis and oro-esophageal candidiasis.

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