Quratulain Shaikh, Ayeesha Kamran Kamal.
Can prophylactic antibiotics for aspiration improve stroke outcomes? the pantheris trial.
J Pak Med Assoc Jan ;64(1):98-98.

Why is this important? Early mortality after ischaemic stroke is attributed largely to stroke associated pneumonia and is reported to be somewhere between 7-22%. Although some patients are at a higher risk of pneumonia following stroke including those within the acute phase (9-36 hours.) and those with non-lacunar stroke in the MCA territory. There is yet no evidence on the outcome of acute stroke if prophylactic antibiotic therapy is given to prevent aspiration pneumonia in high risk patients although some animal studies have suggested benefits of the same. The Preventive Antibacterial Therapy in Acute Ischaemic Stroke (PANTHERIS) trial was done between May 2003 and July 2006 to observe the difference in outcome of acute stroke if prophylactic antibiotic therapy was given.

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