Aj Levra N Giaj, Mantovani C, Trevisan E, Ruda R, Ricardi U.
Spinal intramedullary glioblastoma in a patient previously irradiated for childhood head and neck embryonal rhabdomysarcoma: case report and review of the literature.
J Pioneering Med Students Jan ;4(2):65-8.

Spinal intramedullary glioblastoma localized in cervical spinal tract has rarely been reported in the literature. The most characteristic features are a rapid clinical and radiographic progression and a very poor prognosis. We report a case of a 37-year old man with a diagnosis of cervical spinal intramedullary glioblastoma, with a previous oncological history of a childhood head and neck (epypharyngeal) embryonalrabdomyosarcoma, treated with chemo-radiation therapy in our Department in 1982. The current presentation was with paresthesias/dysethesias on the left side without motor weakness; a brain and spinal MRI showed a contrast enhancing intramedullary lesion at the C2-C5 level, but no evidence of intra-cerebral disease. Biopsy of the intramedullary lesion by C2-C5 laminectomy was performed and cytological analysis revealed a glioblastoma. Radiation treatment was planned with a total dose of 54 Gy to be given in 27 fractions; unfortunately clinical deterioration at a total dose of 32 Gy was noted. Patient developed respiratory distress potentially related to the involvement of respiratory centers; patient died two days after the development of respiratory symptoms.There is little information about cervical spinal intramedullary glioblastoma in the literature and more studies are needed.

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