Naveed Inayat, Riaz Hussain Shah, Qurban Rahoo.
Treatment outcome of multi-drug resistant tuberculosis (MDR-TB).
Pak J Chest Med Jan ;20(4):147-50.

OBJECTIVE: To assess the treatment outcome of multi-drug resistant tuberculosis (MDR-TB). PLACE AND DURATION: People’s University and Medical Health Sciences, Nawabshah during the period of four years from January 2007 to December 2010. MATERIAL AND METHOD: Patients were selected from Pulmonology outpatient department and ward, after having confirmed MDR-TB by Laboratory AFB culture and DST (Drug Sensitivity Test). Patients were admitted in Pulmonology ward till sputum conversion was achieved. The details of demographic data, chemotherapy, adverse reactions to drugs, follow-up assessment as well as regular sputum bacteriology and chest radiograph result were recorded. Medical records were reviewed of patients treated for MDR-TB from January 2007 to 2010 and monitored three years after initiation of treatment. Initial treatment outcomes and survival rates were analyzed. RESULTS: 14 out of 36 patients (38.44%) treatment success rate was found at the end of treatment and 8 patients (22.24%) were failed to achieved sputum conversion by smear and culture at the end of MDR-TB treatment. Where as eight patients (22.24%) were defaulter and 4 patients (11.22%) were died and 2 patients (5.56%) were relapsed after completing their treatment. CONCLUSION: Adequate TB control polices should be implemented to prevent the further spread of drug resistance.

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