Shahab Ahmed, Khurshid Uttra.
Adult osteopetrosis.
Pak Armed Forces Med J Jan ;58(4):467-9.

Osteopetrosis, also called marble bone disease, was first described by Heinrich Albers-Schonberg in 1904 which is a rare hereditary bone disease of heterogeneous pathophysiology in which failure of osteoclastic bone resorption leads to increased bone mass. The primary underlying defect in all types of osteopetrosis is failure of the osteoclasts to reabsorb bone resulting in thickened sclerotic bones, which have poor mechanical properties. Increased bone fragility results from a failure of the collagen fibers to connect osteons properly and from defective remodeling of woven bone to compact bone [1]. This leads to generalized sclerosis of bone with an increased skeletal mass due to abnormally dense bone.

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