Naheed Hashmat, Iffat Shabbir, Tayyaba Rahat, Farooq Ijaz, Saadia Majeed.
Clinical profile and disease outcome of septic patients at public sector hospital.
Pak J Med Res Jan ;54(2):44-7.

Objective: To correlate the clinical profile with disease outcome of patients suffering from septicemia. Study type, settings and duration: This descriptive study was conducted from January to April 2014 at the medical unit of Sir Ganga Ram Hospital Lahore. Patients and Methods: A total of 50 Adults admitted to medical unit of Sir Ganga Ram Hospital Lahore, with signs and symptoms suggestive of systemic inflammatory response secondary to infection were selected and categorized according to criteria by the American College of Chest Physicians (ACCP) and Society of Critical Care Medicine (SCCM). Demographic data. Clinical profile eg and biochemical investigation including liver and renal function tests, coagulation profile, serum electrolytes and serum lactate levels were recorded on a predesigned questionnaire. Data analysis was done by using SPSS-20. Results: A total 50 patients were admitted with septicemia. They were distributed as per ACCP criteria into three classes i.e. sepsis 25 (50%), severe sepsis 16 (32%), and septic shock 09 (18%). The most common causes of sepsis were urinary tract infection (46%); followed by pneumonia (32%); gastroenteritis (16%) and others (06%). E.coli was the predominant organism isolated in 44.5% urine samples. Comorbids included, 22% diabetics, 16% chronic kidney disease, 14% hypertensive, 10% chronic liver disease, 10% pulmonary tuberculosis and 4% cases chronic obstructive airway diseases. Out of 50 patients, 35 (70%) recovered and 15 (30%) expired. Disease severity was directly related to the mortality and 78% cases having septic shock expired as compared to 31% with severe shock. Comorbids, blood CP and serum lactate level did not show any significant association between disease severity and its outcome. Conclusion: Disease severity was directly related to disease outcome. No association found between serum lactate, disease severity and its outcome. Policy Message: Standardized management protocol adapted from the current guidelines particularly low-cost interventions targeted at early sepsis needs to be developed and implemented.

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