Sadaf Baqai, Muhammad Zeeshan, Saleem Hafeez, Syed Kashif Raza, Parpoola Kumari.
Pathogens causing Bacteremia in Patients with Urinary Tract Infection in Urology and Nephrology Units of a Tertiary Care Hospital in Karachi, Pakistan.
Infect Dis J Jan ;22(1):525-7.

Background: In urology and nephrology units the rate of urinary tract infections and its complication is one of the main infective causes of mortality and morbidity. Early and prompt antibiotic therapy based on the knowledge of the prevalent microorganisms can help reduce this rate. The objective of the study was to assess the microbiology and rate of bacteremia causing urinary tract infections in the urology and nephrology unit of our institute. Methods: This was retrospective study over 4 month period (July to October 2010); 103 paired urine and blood samples from urology and nephrology unit received in the clinical laboratory were analyzed. Microbiological data was retrieved from laboratory data base. Cultures were performed using standard microbiological methods. Organisms were identified using routine biochemical tests. Antibiotic susceptibility testing was performed with Kirby-Bauer disc diffusion method using Clinical laboratory standard institute (CLSI) standards. Results: Significant bacteriuria was found in 68% and 31% had only bacteremia. E.coli was the most commonly isolated organism from blood and urine culture, 60% were extended spectrum beta lactamases producers. About 14% of the patient had concordant organisms in blood and urine cultures and were labeled as urosepsis, while 6% patients had disconcordant results with different organisms in blood and urine and 8% had negative urine culture and positive blood cultures. Conclusion: Rates of urinary tract infection are high and lead to bacteremia in one third of the patients and can be reduced with stringent infection control practices.

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