Inam F, Tahir M, Lone Kp, Latif W.
Protective effect of vitamin E on fluoride induced hepatotoxicity.
Biomedica Jan ;31(1):1-6.

Fluoride salts generate free oxygen radicals which cause lipid peroxidation resulting in cell membrane damage and toxicity. Morphologically toxicity to liver is manifested as ballooning degeneration of cells, necrosis and infiltration of mononuclear cells in hepatic lobules. Aims and Objectives: The present experimental study is designed to investigate the toxic changes in the liver of sodium fluoride treated mice and evaluate the protection provided by vitamin E. Four groups with 12 animals in each are used. Materials and Methods: Group A was given olive oil 6.67 ml/kg/day orally for 30 days. Group B was given sodium fluoride 10 mg/kg/day dissolved in distilled water + olive oil 6.67 ml/kg/day both orally for 30 days. Group C was given sodium fluoride 10 mg/kg/day dissolved in distilled water and vitamin E 15 mg/kg/day dissolved in olive oil both orally for 30 days. Group D was given vitamin E 15 mg/kg/ day dissolved in olive oil orally for 30 days. Results: On histological examination, animals of group B showed altered structure of hepatic lobules with deranged radiating hepatocytes, many of which manifested ballooning degeneration and statistically significant increase in their size (p-value < 0.001), vacuolation, presence of necrotic foci and periportal inflammation. These deranged histological findings were correlated with elevated levels of liver enzymes in serum. Co-administration of vitamin E and sodium fluoride to animals of group C showed statistically significant prevention of signs of degeneration in hepatic lobules. Conclusion: Fluoride induced hepatotoxicity is effectively prevented by co-administration of Vitamin E treatment.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com