Tahir Nazeer, Naila Akhtar, Muhammad Younas, Amna Tahir, Tanveer Akhtar Butt, Muhammad Azam.
Comparison of single dose of omeperprazole (20mg) versus esomeprazole (40mg) on gastric acidity.
Biomedica Jan ;30(2):106-9.

Objective: The objective of this study was to evaluate and compare the effectiveness of single dose of omeprazole 20mg and esomeprazole 40mg on stomach pH. Material and Methods: In this study 50 patients, of ASA class p1 and p2 status, of age 15 to 60 years and body mass index (BMI) 20 to 35 kg/m2 undergoing inguinal hernia surgery electively of both sexes were included. In group “O” 20 mg Omeprazole and in group “E” 40 mg Esomeprazole was given to all parti- cipants on the night before surgery at 10 pm and were asked to remain nothing per orum after mid- night. In morning after induction of general anaesthesia a multiorifice nasogastric tube (16F) was pas- sed in stomach and verified by auscultation over epigastrium with 10ml air. Gastric fluid was with- drawn in a sterile syringe and transferred to a sterile test tube. pH was determined by calibrated pH paper and was confirmed by pH meter. Nasogastric tube was then removed. Results: In group “O” the median range of gastric fluid pH was 4.5 (1.5 – 7.0). In group “E” it was 7.0 (3.0 – 8.0). P value not significant. Conclusion: Single oral dose of Esomeprazole 40 mg at bed time before surgery has same efficacy in in- creasing the intragastric pH like single oral dose of Omeprazole 20 mg.

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