Naeem Raza Hamdani, Nasira Shaheen, Muhammad Usman Rathore, Saba Anjum, Muhammad Shahbaz Amin, Adeel Arif, Abdul Qadir, Kaswar Sajjad Ansari.
Fine Needle Aspiration Cytology Breast Lesions - Its Concordance with Histopathological Examination of Excised Lesion.
J Rawal Med Coll Jan ;19(1):41-3.

Background: To assess the accuracy of fine needle aspiration cytology and comparing it with histopathoogical examination of excised lesion. Methods: In this cross sectional study palpable breast lumps referred for FNAC were included. Fine needle was used to aspirate the palpable lump and spread on the frosted slides to make the smears. These smears were fixed in ethyl alcohol and stained. Diagnosis was given along with categorization of the lesion using an internationally recommended reporting format. Sensitivity, specificity and diagnostic accuracy of FNAC was calculated using 2 x 2 table keeping histopathology as gold standard and FNAC as test. Results: Out of 73 patients majority (93%) were females. Age ranged between 10 to 80 years with mean age of 38 years (± 17). Right breast was involved in 66% cases and bilateralism was seen in 4%. Definite diagnosis was given in 85% cases with 63% reported as benign and 22% reported as malignant. There were no false positive cases and two false negative cases were reported. Sensitivity and specificity of breast FNAC in the diagnosis of malignancy was found to be 89% and 100 % respectively Conclusion: FNAC of palpable breast lumps is a reliable method for early diagnosis and management of lesions and the false negative results can be eliminated by examining the slides carefully before giving a negative diagnosis.

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